Recent Projects at TAP Biosystems (now part of the Sartorius Stedim Biotech Group)
Arnaud Miège's Web Site: Home > Recent Projects at TAP Biosystems (now part of the Sartorius Stedim Biotech Group)
I work as a Mechanical Engineer for TAP Biosystems (now part of the Sartorius Stedim Biotech Group), a leading global provider of automated cell culture and fermentation systems for life science research, development and production.
As a mechanical engineer:
I lead the hardware development of complex automated systems containing hardware, electronics and software for pharmaceutical and biotechnology applications world-wide;
I lead a small team of mechanical and electrical designers to ensure that the hardware design's quality, time and cost targets are met;
I work closely with key stakeholders including, software, business development and technology to ensure that the system design meets the essential requirements for commercial success;
I contribute towards the production engineering and cost reduction of existing and emerging products to ensure the designs meet the requirements for a successful product release.
My key job accountabilities are:
to lead the Hardware technical design and development associated with the development through to completion;
to ensure that cost and quality targets are achieved within agreed timescales;
to arrange, participate in, or facilitate design reviews with peers and others;
to ensure an effective hand over to the products group and a successful production release;
to follow TAP Biosystems' development and engineering processes.
Here are some of the projects/products I have worked on recently (all development work involves liaising with the design engineers and working in CAD, using Autodesk Inventor):
ambr® crossflow is a novel high throughput solution for parallel crossflow screening. I have recently taken technical leadership for this new product.
ambr® 250 modular is a new high performance, single-use benchtop bioreactor system for parallel fermentation or cell culture. I am the Design Authority for this product, and oversaw all aspects of the design, for both hardware and labware (consumable), before helping the transition from R&D into manufacturing.
SampleSeal Heat Sealer: seals and individualises 96- and 384-format 2D-barcoded storage tubes in a single process. The foil-sealed tubes can be reliably stored at temperatures from -196° to +25°C, and easily pierced with manual or automated pipette tips, supporting compatibility across standalone or integrated storage applications. I took over as Design Authority for the product, ensuring a smooth transition to the distributor.
ambr® 250 is a new fully automated bioreactor system for fermentation or cell culture. I co-led the design, build and commissioning of the bioreactors of the first two systems. This included various components, such as the feed pumps for the bioreactors, off-gas analysis, gassing & cooling manifolds, as well as the numerous sensors to characterise and calibrate (temperature, pressure, O2, CO2, mass flow, pH, etc... This work involved defining calibration and test procedures, acceptance criteria, etc... from an individual bioreactor level to a system-level. I also collaborated with software and electronics engineers to debug and refine the firmware and software on the system, as well as manufacturing engineers and product managers to roll out a number of ancillary consumable products for ambr® 250.
RAFT (Real Architecture for 3D Tissue) is a new system to enable scientists to create complex 3D cell cultures from collagen, in a convenient, simple-to-use format (subsequently sold to Lonza). I looked after all engineering-related aspects of the product, in particular the quality control of the assemblies and parts from suppliers, in conjunction with manufacturing engineers at TAP Biosystems. This involved performing some statistical analysis and Monte-Carlo simulations of the measurements taken in eahc batch.
I took part in the evaluation of modelling and simulation tools (mainly Scilab and GNU Octave) for the hardware engineering group, leveraging on my experience at MathWorks. Criteria were the ease-of-use and functionality of different software packages to create mathematical models from first principles, as well as from measured data, and to design and fine-tune control system algorithms.
ambr® crossflow is a novel high throughput solution for parallel crossflow screening, designed as benchtop crossflow system optimised for ultrafiltration and diafiltration applications.
ambr® 15: new advanced microscale bioreactor system for cell line development. ambr® mimics the characteristics of classical bioreactors at microscale (10-15ml), by using cost effective, disposable micro bioreactors, controlled by an automated workstation.
ambr® 250: new fully automated bioreactor system for parallel fermentation or cell culture, using single use 100-250ml reactor vessels with a novel "easy connect" process enabling all gas, liquid and sensor connections to be made, quickly and simply, for fast turnaround between experiments.
ambr® 250 modular: new high-performance, single-use benchtop bioreactor system for parallel fermentation or cell culture. It combines bioreactor stations, a control module and software to allow users to set up experiments quickly and easily, enabling them to focus more on the science. In addition, a new fully integrated vessel design eliminates the need for sterilization and reduces the risk of human error.
fill-it: standalone benchtop product for dispensing cell suspensions and other liquids into screw-cap microtubes and cryovials, and includes automation for removing and replacing the tube caps.